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When you buy an off-the-rack mountain bike, its suspension fork will most likely be adjusted for a 150 to 170 pound rider. So, if you weigh more or less than that, you should change the adjustment. Without changing the adjustment, your comfort level and control over bumps will suffer, as will your fork.
If you weigh under 150 pounds, explore your other options. You might want to think about having a bike built to fit your body type perfectly. If you're already set on a specific bike, however, you can have it customized to fit your needs.